Abstract Numerous studies have shown that conjugated imidazo[1,2-a]pyridine derivatives possess various kinds of biological activities, including antibacterial properties. In this work, we designed and synthesized fifteen (15) imidazo[1,2-a]pyridine-chalcone derivatives (4a-o) and studied their antibacterial activity. These compounds were obtained by Claisen-Schmidt condensation between imidazo[1,2-a]pyridine-3-carbaldehyde derivatives (2a-b and 3) and acetophenone derivatives in the presence of […]

Abstract Centella asiatica is an important and commonly used herbal medicine that can be traced back a long way in the history of Chinese medicine. It contains a variety of active ingredients, mostly triterpenes. Asiatic acid (AA) is a pentacyclic triterpenoid that existed in Centella asiatica, which exhibits efficient anti-inflammatory and anti-cancer activities. Since there […]

Abstract Phosphodiesterase type 5-inhibitor (PDE5-i) such as sildenafil and its analogues are among the most popular medicines bought through online retailers. Many reports however show that these products often are of poor quality or do not have a marketing authorization in the recipient country and thus may pose serious health threats to consumers. Qualitative and […]

Abstract The current study was undertaken to assess the complementary action of pepper as bioenhancer in the treatment of cancer along with mercaptopurine. Haemoglobin content and RBC count were significantly decreased and total WBC count was significantly increased in the tumour group as compared to the normal group. Treatment with both Mercaptopurine (5mg/kg) and Piper […]

Abstract Cycloastragenol (CAG), a telomerase activator, is a tetracyclic triterpenoid isolated from Astragalus membranaceus. CAG can be prepared by hydrolysis of astragaloside IV (ASI) using three methods: acid hydrolysis, enzymatic hydrolysis and Smith degradation. In addition, the structure of CAG has been modified by chemical modification and microbial transformation, and many modification products have been […]

Abstract Microencapsulation is described as a process of enclosing micron-sized particles of solids or droplets of liquids or gasses in an inert shell, which in turn isolates and protects them from the external environment. Hot-melt granulation (HMG) has gained interest in the pharmaceutical field as a processing technology capable of producing solid dispersions with a […]

Abstract Juice were produced from orange, apple, pineapple and a mixture of the three fruit samples.  They were preserved using different methods of preservation for four weeks. The physico-chemical parameters of the juices was investigated. Juice was extracted from the fruit samples and pasteurized for four minutes at 65 °C. The juice concentrate was then […]

Abstract Vascular endothelial cells play a very important role in human tissues, which is an important link to determine health. As the covering cell of vascular intima, it not only has the function of regulating vascular pressure and phagocytosis of bacteria and senescent cells, but also has the function of releasing cytokines to regulate cell […]

Abstract Terpenoids, as an important class of organic compounds, are widely distributed in nature and have many biological activities, such as antioxidant, anti-inflammatory, anti-cancer, anti-aging, antibacterial. Aging is an unavoidable natural phenomenon, intervened by factors such as oxidative stress, inflammation, and declining immune function. Anti-aging has been a hot research topic in recent decades, and […]

Abstract Due to the excellent pharmacological effects of polysaccharides, scholars have attached importance to researches on them. However, the high-value utilization and development of polysaccharides have been greatly limited by the high molecular weight, poor solubility and bioavailability. The degraded polysaccharides have stronger biological activities than those before degradation, such as antioxidant, anti-tumor, immune-regulatory, anti-hyperlipidemia, […]