Abstract CSCs have been regarded prospective therapeutic targets for cancer therapy since they were initially discovered in leukaemia in 1994. These cells have the ability to self-renew and differentiate, and they contribute to a variety of tumour malignancies, including recurrence, metastasis, heterogeneity, multidrug resistance, and radiation resistance. Several pluripotent transcription factors, including OCT4, Sox2, Nanog, […]

Abstract Polysaccharides that widely exist in seaweed have many biological activities such as regulating immunity, anti-tumor, anti-blood lipid and hypoglycemic. They are widely used in a verity of industries. Therefore, the research of seaweed polysaccharide has always been the focus. In this paper, the recent advances in the extraction, separation and purification of seaweed polysaccharides […]

Abstract The identification of mutationally activated BRAF in many cancers altered our conception of the part played by the RAF family of protein kinases in oncogenesis. In this Review, we describe the development of BRAF inhibitors and the results that have emerged from their analysis in both the laboratory and the clinic. We discuss the […]

Abstract HPLC (LC-2010-HT, Shimadzu, Singapore) method for analysis of Anastrozole was carried out by the C-18 column (Inertsil, ODS 3V, 250mm X 4.6mm; 5µ) using a mobile phase consisting of buffer-acetonitrile (1:1) with the pH 2.5 adjusted by using buffer. 0.02 M KH2PO4. The mobile phase was pumped at the rate of 1.1 ml/ min […]

Abstract Phytochemicals, elemental composition and antioxidant activity of ethanolic extract of Pueraria phaseoloides leaves were investigated. The results showed the presence of six Phytochemicals: alkaloids, flavonoids, saponins, tannins, steroids and phenols. The micro and macro elements were determined using Flame Photometer and Atomic Absorption Spectrophotometer. The analyses revealed the presence of: calcium (2.44±0.087 mg/kg), Magnesium […]

Abstract Celastrus paniculatus (CP), a traditional Ayurvedic medicinal plant used for centuries as a memory enhancing, anti- inflammatory, analgesic, sedative and antiepileptic agent. The seed extract has been extensively investigated in several laboratories for their neuropharmacological effects and a number of reports are available confirming their nootropic action. In addition, researchers have evaluated the anti-inflammatory, […]

Abstract Embelia ribes Burm. f. is a threatened medicinal plant, studied extensively for its rich medicinal properties. It has been used in ayurvedic formulations from the ancient times and in the recent past a surge of research on this particular medicinal plant species has been undertaken. This particular species is found to attribute to a […]

Abstract Pharmaceutical Care is a patient-centered, outcome-oriented pharmacy practice that requires the qualified pharmacist to work in concert with the patient and the patient’s other healthcare providers to promote health, to prevent disease, and to assess, monitor, initiate, and modify medication use to assure that drug therapy regimens are safe and effective. The goal of […]

Abstract Cancer is defined by means of uncontrolled tumour growth boom precipitated via ordinary cell cycle protein activity. As a result, cell cycle regulators are famous goals in most cancers therapy. Surprisingly, animal studies exhibit that some of these proteins are now not required for non-transformed cell proliferation or tissue growth. Many malignancies, on the […]

Abstract Self-emulsifying drug delivery systems, which are isotropic mixtures of oils, surfactants, solvents, and co-solvents or surfactants, may be used to design formulations to boost oral absorption of highly lipophilic drug compounds. It may be orally administered in soft or hard gelatin capsules. These systems form fine emulsions or micro-emulsions in the gastro-intestinal tract with […]