Abstract Numerous studies have shown that conjugated imidazo[1,2-a]pyridine derivatives possess various kinds of biological activities, including antibacterial properties. In this work, we designed and synthesized fifteen (15) imidazo[1,2-a]pyridine-chalcone derivatives (4a-o) and studied their antibacterial activity. These compounds were obtained by Claisen-Schmidt condensation between imidazo[1,2-a]pyridine-3-carbaldehyde derivatives (2a-b and 3) and acetophenone derivatives in the presence of sodium hydroxide (NaOH). The synthesized compounds were characterized by NMR spectroscopic analyses (1H, 13C NMR). The antibacterial activity of these 15 derivatives was determined against Escherichia Coli strain by disc diffusion method. The results showed that three (3) of these 3-imidazo[1,2-a]pyridinyl-1-arylpropenone (4e, 4n and 4o) derivatives were active with inhibition diameters between 8 and 15 mm. The 4e compound was the most potent with a diameter of 15 mm.
Keywords imidazo[1,2-a]pyridine, arylpropenone, NMR spectroscopic analyses antibacterial, inhibition diameter