Abstract Cycloastragenol (CAG), a telomerase activator, is a tetracyclic triterpenoid isolated from Astragalus membranaceus. CAG can be prepared by hydrolysis of astragaloside IV (ASI) using three methods: acid hydrolysis, enzymatic hydrolysis and Smith degradation. In addition, the structure of CAG has been modified by chemical modification and microbial transformation, and many modification products have been obtained. According to the study, CAG was shown to possess several biological activities, including anti-aging, anti-cancer, anti-inflammatory, anti-osteoporosis, and anti-neurodegenerative diseases. This paper reviews the preparation methods, structural modifications and pharmacological activities of CAG that have been studied in recent years.
Keywords Cycloastragenol, Preparation Methods, Pharmacological Activities, Structural Modifications.