Abstract This study is aimed at determining the levels of sixteen (16) polycyclic aromatic hydrocarbons (PAHS) in sediment samples from Gubi Dam, Bauchi State, Nigeria. Sediment samples were collected at four different sampling points designated S1 to S4. Extraction and clean-up of sediment samples were carried out using GC-MS. The Dam under study was classified […]
Evaluation of ethnopharmacologically selected Indian medicinal plants for their classes of Phytochemical and biological activities
Abstract The ethnomedicinal values of plants form the basis of the herbal drug industry. India has contributed its knowledge of traditional system medicines (Ayurveda and Siddha) to develop herbal medicines with negligible side effects. The World Health Organization has also recognized the benefits of drugs developed from natural products. Abutilon indicum, Hibiscus sabdariffa, Sida acuta […]
Purine analogs Synthesis, Molecular Docking Studies and ADME Properties of Some New Pyrazolo[1,5-a]pyrimidines and Evaluation of their Antimicrobial and Anticancer Activities as CDK inhibitors
Abstract Cancer and antibacterial resistance threaten global health. Purine anti-cancer analogues are Nucleoside triphosphates and antimetabolites compete for DNA/RNA synthesis. new Pyrazolo[1,5-a]pyrimidine (5a-b) compounds were synthesized to test their antibacterial efficacy in vitro against microbial species, but give no activity Compared to 4 mg/mL Gentamycin (13mm and 11mm inhibition zones). In vitro antitumor activity of […]
The Neuroprotective Mechanism of Antrodia Camphorata on the Ischemic Cerebral Cortex is Correlated to the Alterations of Lipid Peroxidation Status and Essential Element Concentration
Abstract Antrodia camphorata (AC) has been suggested as an alternative Chinese medicine commonly used to protect and treat liver diseases due to its beneficial functions of anti-inflammation and anti-oxidation. Essential element of magnesium (Mg), zinc (Zn), iron (Fe), and copper (Cu) is required for brain functions. Our study was to explore whether antrodia camphorata is […]
Preliminary Studies of 4-Phenylimidazole-2-Thione Alkylation: Kinetic or Thermodynamic Products
Abstract In this work, we designed 4-phenylimidazole-2-thione by a simple grinding method and the resulting compound reacted with alkylating agents. Seven alkyl derivatives were obtained with yields of 13-58%. Substituted compounds in positions 1 and 3 (5a-c) were obtained with yields higher than those substituted in positions 1 and 2 (4a-c) or substituted in positions […]
Role of Enzymes in Plant Defense Against Phytopathogenic Fungi
Abstract Abiotic (cold, drought, heavy metals, salinity, wounding) and biotic (plant parasite organisms) stressors frequently inhibit plant growth and development. One of the most harmful plant parasite organisms, phytopathogenic fungi, can cause severe diseases and major yield losses in crops. By physically strengthening their cell walls through lignification, suberization, and the production of various defense-related […]
New therapeutic precursors isolated from Arbus precatorius (Fabaceae) a plant used against infections in Benin
Abstract We have contributed to the valorization of a flora plant of beninese used traditionally in antibacterial infections. We have prepared hydroethanolic extract from powdered dried leaves of Arbrus precatorus (Fabaceae).We did a split bioguided from the crude hydro-ethanolic extract. We have isolated and purified by the series of methods chromatography two flavonoids from the […]
The Protective Activity of Bridelia ferruginea against Cardiac Injury Induced by Diclofenac in Wistar Albino Rats
Abstract Bridelia ferruginea is an indigenous medicinal plant in Nigeria belonging to the Euphorbiaceae family and is used for diverse medicinal purposes. The present study aimed to determine the cardiac protective property of methanol extract of Bridelia ferruginea against diclofenac-induced cardiac damage in wistar albino rats. Fifty (50) wistar rats (weighing about 150-200kg) were used […]
Managing Resistant Hypertension – A Comprehensive Overview
Abstract Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a long-acting calcium channel blocker, a blocker of the renin-angiotensin system (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker), and a diuretic. The antihypertensive drugs should be administered at maximum […]
Bioaccumulation and Oxidative Stress of Aluminum Oxide Nanoparticles in some Brain Regions of Male Albino Rats
Abstract This study aimed to assess oxidative stress in the hippocampus, cortex, striatum, and midbrain of male rats in response to Al ions accumulated in these areas following nasal instillation of nano-alumina (Al2O3NPs) every other day. Rats were divided into groups I and II. The first group was administered deionized water (control), whereas the second […]