The wealth of latest data and knowledge relating to epigenetics obtained in recent years highlights a vibrant future for epigenetics research.  It involves the integration of high-throughput sequencing technologies and the means to maintain and manipulate the large amount of data produced by sequencing epigenomes. As more epigenetic markers are associated with specific diseases and […]

Abstract Medicinal plants produce several antibacterial compounds. These plants are well known for their medicinal value and are widely used in community for the treatment of various diseases. In this study 5 different medicinal plants (Azadirachta indica, Ficus religiosa, Acacia nilotica, Linum usitatissimum and Rosa damascene), traditionally used in medicine, were subjected to preliminary screening […]

Abstract Potassium Permanganate (KMnO4) is an oxidizing agent widely used throughout the water industry. It has an effect on the development of a disinfection strategy by serving as an alternative to pre-chlorination or other oxidants at locations in a treatment plant where chemical oxidation is desired for control of color, taste, odor and algae. Potassium […]

Abstract A new simple, precise, accurate and cost effective UV spectrophotometric method has been developed for the estimation of Cefpodoxime and Ofloxacin in combined dosage form by simultaneous equation method. This method utilized methanol: 0.1 N HCl (50:50) as common solvent. The wavelength selected for simultaneous equation method for Cefpodoxime shows maximum absorption at 276 […]

Abstract The aim of the current study is to design a sustained release matrix tablet of metformin HCl to maintain plasma level of drug for prolong period of time. Metformin HCl is antihyperglycemic agent used in the treatment of type II Non insulin dependent diabetes mellitus. Sustained release formulation of metformin HCl prolong drug absorption […]

Abstract One simple and sensitive spectrophotometric method has been developed for the quantitative estimation of Lafutidine from tablet. The method was developed and based on the solubility of Lafutidine in 0.1 N HCl (pH 1.2). The drug showed maximum absorbance at 286 nm and linearity (Lambert Beer’s Range) was found in concentration range of 10-60 […]

Abstract The hypoglycemic effect of ethanolic leaves extract of Zizyphus nummularia was evaluated by alloxan-induced diabetic rats. Animals were induced alloxan for diabetes with (150 mg/kg bw i.p.) and treated orally with ethanolic leaves extract of Zizyphus nummularia (250 mg/kg & 500 mg/kg) and standard Glibenclamide (5 mg/kg). The extracts showed significant (p< 0.01& p< […]

Abstract A simple, fast, accurate and precise reverse phase high performance liquid chromatographic method has been developed for the estimation of Griseofulvin in oral suspension. The chromatographic separation was achieved on Zorbax eclipse plus C8 (250 x 4.6) mm; 5µm particle size column with a gradient mixture of mobile phase containing acetonitrile: ortho-phosphoric acid buffer: […]

Abstract This study has explored the use of self-emulsifying drug delivery system (SEDDS) to enhance the oral bioavailability of the poorly water soluble drug eprosartan. On the basis of solubility studies Labrafac Lipophile WL 1349 was selected as oil phase, Tween 80 as surfactant and capryol 90 as cosurfactant. Pseudo-ternary phase diagrams were plotted to […]

Abstract In the present investigation we were aimed to investigate the antioxidant potential of various crude extracts of leaves of Solanum nigrum. The extraction was carried out by different solvent such as petroleum ether, ethyl acetate and chloroform. The antioxidant property of these extracts was assessed by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. Keywords  […]