Abstract One simple and sensitive spectrophotometric method has been developed for the quantitative estimation of Lafutidine from tablet. The method was developed and based on the solubility of Lafutidine in 0.1 N HCl (pH 1.2). The drug showed maximum absorbance at 286 nm and linearity (Lambert Beer’s Range) was found in concentration range of 10-60 μg/ml and the standard curve equation was found to be y = 0.015x – 0.015 and R2 value 0.997. The results of analysis were validated statistically and by recovery studies. The result of analysis was validated as per ICH guidelines and this method can be used for the routine analysis of Lafutidine formulation.
Keywords Lafutidine, Buffer pH 1.2, UV method, Validation