Abstract  Objective: This study aims to explore the molecular mechanism by which DCI improves MAFLD induced by diabetes by pyroptosis, and to bring new ideas for clinical treatment and reversal of MAFLD. Methods: In this study, we investigated the effect of DCI on macrophage pyroptosis using a diabetic mouse model (db/db mice) and high glucose […]

Abstract The toxicity of sniper – containing 2, 3-dichlorovinyl dimethyl phosphate (DDVP) on fingerlings and post fingerlings of Clarias gariepinus (African catfish) was investigated in a static bioassay for 96 hours. 100 pieces of fingerlings and 100 post fingerlings fishes weighing between 1.2g – 1.4g were obtained from a fish farm and transported to the […]

Abstract Cancer is a complex and multifaceted biological phenomenon characterized by the dysregulation and excessive proliferation of cells, ultimately leading to uncontrolled growth. It represents a significant contributor to global mortality rates. The documented cases and projected outcomes for the immediate future are beyond imagination. According to statistics from the FDA, it has been observed […]

Abstract The present study succeeded in the formulation and evaluation of biodegradable films of levofloxacin for the management of periodontitis. Processing factors such as chitosan and plasticizer concentration have significantly affected the physical characteristics of film and were found within acceptable range. Chitosan concentration has negatively affected drug release and positively affected T90 due to […]

Abstract Microspheres play a very important role as particulate drug delivery system because of their small size and other efficient properties. These have been proved to be a suitable bridge to scale the distance over to formulate an effective dosage form, so simulate controlled drag release. These microspheres are used for drug delivery, wherein the […]

Abstract According to Thun, DeLancey, Centre, Jemal, and Ward (2009), cancer ranks as the third most significant contributor to both morbidity and mortality on a global scale. Despite the absence of dedicated pharmaceutical interventions, radiotherapy (RT) serves as the primary therapeutic modality for cancer, with more than 60% of cancer instances necessitating radiation therapy. Radiation […]

Abstract Sitagliptin, a widely used antidiabetic agent, poses challenges in achieving precise and sustained drug release due to its biopharmaceutical properties. In response to these challenges, this study focused on the design and development of an osmotic drug delivery system for Sitagliptin. The research employed a combination of formulation techniques, including drug-polymer compatibility studies and […]

Abstract The dramatic increase of different human activities around the surface water system.The assessment of surface water suitability for drinking purpose is needed for water sustainability. The Water Quality Index (WQI) is an approach to identify and assess the drinking water quality suitability. Water crises and quality are serious concerns in a lot of countries, […]

Abstract Nano-alumina toxicity refers to the potential harmful effects of nanoparticles of alumina on living organisms and easily penetrate all tissue and across blood brain barrier. The aim of the present study to conducted the correlation and physiological affected parameters under acute Al toxicity. The study started with twenty rats divided into two groups 10 […]

Abstract The aim of present study is to formulate and evaluate the bilayered tablets containing Rosuvastatin as immediate release (IR) portion and Metformin Hydrochloride as sustained release (SR) portion in order to produce a single tablet containing two different classes of drugs as widely prescribed by doctors and to have better patient compliance. The sustained […]