Abstract The present study succeeded in the formulation and evaluation of biodegradable films of levofloxacin for the management of periodontitis. Processing factors such as chitosan and plasticizer concentration have significantly affected the physical characteristics of film and were found within acceptable range. Chitosan concentration has negatively affected drug release and positively affected T90 due to altered matrix density. On the contrary, plasticizer concentration has positively affected the rate of drug release and negatively affected T90 of drug attributed to increased membrane permeability. This study succeeded in the fabrication of levofloxacin biodegradable, mucoadhesive chitosan film which is cheap, less resource-requiring film devices having greater market potential to administer medicament locally into the periodontal pockets for the management of periodontitis.
Keywords Formulation, Evaluation, Biodegradable Films, Levofloxacin, Periodontitis.