Abstract Nano-alumina toxicity refers to the potential harmful effects of nanoparticles of alumina on living organisms and easily penetrate all tissue and across blood brain barrier. The aim of the present study to conducted the correlation and physiological affected parameters under acute Al toxicity. The study started with twenty rats divided into two groups 10 rats for each: Control group (Con), Toxic group (Al-Nano) received single dose of intranasal (1.66g/kg Al2O3NPs) then all rats were scarified and brain dissected to four brain area (Hippocampus, Cortex, brain stem, and midbrain). Our results suggest that the Al2O3NPs stimulate the positive correlation between aspartic acid, glutamic acid, 5HIAA and negative correlation between aspartic acid, glutamic acid, 5HIAA vs. Glycin, NE, DA, 5HT, and GABA levels. In the same manner there were positive correlation between Glycine, NE, DA, and 5HT level for each brain area with different potent correlation level. This study concluded that Al2O3NPs exerted the negative cascade of monoamines concentration and secretion concurrent with the high level of aspartic, glutamic acid and serotonin metabolites (5HIAA).
Keywords Nano-alumina Correlation, Monoamines and amino acids, Brain, Rats..