Abstract The objective of this study was to design and evaluate oral sustained drug delivery system for metoprolol succinate using hydrophilic polymers such as HPMC K4M and HPMC K100M batches. Four batches were prepared by using HPMC K4M in drug: polymer ratio of 1:1, 1:1.5, 1:2, 1:3 and five batches using HPMC K100M in ratios […]

Abstract The fruits of Lycium chinense Miller (Solanaceae) possess emmenagogue, diuretic, antipyretic and hepatoprotective properties and are used to stimulate the immune system, to increase hormonal growth, to improve blood circulation and eye sight and to cure morning sickness. Phytochemical investigation of a chloroform extract of the fruits gave two new aliphatic esters, characterized as […]

Abstract In this research six of N-phthalimides of amino acids (IIIa-f) have been synthesized, as a first step, through cyclocondensation of o-phthalic acid with amino acids (glycine, L-alanine, L-valine, L-leucine, L-phenylalanine, L-aspartic) in the presence of glacial acetic acid in bath oil (170-180 oC), the results of this step were compared with the results of […]

Abstract Medicinal usage of plants is one of the superior characteristic on which mankind is dependent upon since ages. Plants are being used for the treatment of various diseases of humans and animals. The Changa Manga Forest is designated as National Park located in Kasur, District. It consists of vast biological panorama, constituting many plants […]

Abstract Molecular dynamic docking simulations for 100 pico-seconds were performed for all the possible alignments of Celiprolol in complex with β-cyclodextrin “Celiprolol-β-CD” complexes on the level of molecular mechanics and calculations of interaction energies were performed. The computational calculations for the inclusion complexes of the S- and R-β-CD rationalized the reasons for the different migration […]

Abstract In the current exploration a novel oral drug delivery system was developed utilizing the concepts of controlled release and mucoadhesiveness. Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesive microspheres exhibited a prolonged residence time at the site of application or absorption and facilitate an intimate contact with […]

Abstract The increasing use of ionizing radiation in medical field is at present by far the largest source of exposure of the population. For this reason, radiation protection measures should be taken by each country to prevent unnecessary radiation exposure. Medical Physicists play a key role in patient dose management. Entrance skin dose (ESD) is […]

Abstract A novel flavonol glycoside has been isolated from the ethyl acetate fraction of the stem bark of the Sida rhombifolia. The structure of the new compound has been established as 5, 7-dihydroxy-4′-methoxy flavonol-3-O-β-D-glucopyranoside based on the spectral data using UV, IR, 1H-NMR, 13C-NMR and Mass. Keywords Sida rhombifolia, Flavonol Glycoside Google Scholar Citation [Full […]

Abstract The present study was conducted to develop a new simple, rapid, precise, sensitive, eco-friendly UV-spectroscopic method for the quantitative determination of Pefloxacin Mesylate in bulk form and prepared in-situ gelling ocular formulations. Method was successfully developed in simulated tear fluid pH 7.4 and further validated in accordance with International Conference on Harmonization (ICH) Q2B […]

Abstract Plants which endowed medicinal values are held at the highest rank in folk medicinal systems throughout the world. The locally suggested remedies and the ethno-botanical knowledge for this purpose, whether it’s traditional or modernized, have its roots into the belief in folk medicinal knowledge of the particular region. This study was conducted at Gatwala […]