Abstract Many different strategies of high performance liquid chromatographic method development are being used today. This overview describes a strategy for the systematic development of High performance liquid chromatographic (HPLC) methods. It is an analytical tool which is able to separate, detect and quantify the drug, its various impurities and drug related degradants that can […]

Abstract A simple, rapid, accurate and precise RP-HPLC method was developed and validated for simultaneous estimation of Azilsartan medoxomil and Amlodipine besylate in synthetic mixture. The chromatographic separation was carried out on Hypersil ODS C18 column (250×4.6 mm; 5µ) with mixture of 0.2% ortho-phosporic acid in water :acetonitrile (35:65% v/v) as a mobile phase; at […]

Abstract A simple, accurate and precise RP-HPLC method was developed for simultaneous estimation of Betamethasone dipropionate, Tolnaftate and Iodochlorhydroxyquin. EclipseC18 (250mm×4.6mm) 5µ (particle size) was used as stationary phase. The mobile phase used was KH2PO4 buffer of pH 6.3: Acetonitrile 30:70 V/V. The mobile phase was delivered at flow rate 1.5 ml/min. UV detection was […]

Abstract The study reports modeling of laminar film condensation of horizontal flat plate with hot vapor film exists above the plate with higher temperature (saturation temperature). In this study mathematical expressions for film thickness, velocity and temperature profile were obtained analytically. Models confirm that velocity and temperature depend on the distance from plate center (x), […]

Abstract Carbapenem-resistant Enterobacteriaceae has challenged the therapeutic efficacy and raised the most worrisome global issue of public health importance. The study was conducted to determine the burden of carbapenem resistant isolates of Enterobacteriaceae producing different types of β-lactamases. During the study period, a total of 310 enterobacterial pathogens were isolated and identified from the clinical […]

Abstract The present research was aimed to design controlled release suspension formulation of BCS class I drug Tramadol hydrochloride a centrally acting synthetic analgesic. Complexes of indion 244 ion-exchange resin and tramadol hydrochloride, a model drug, were prepared using a batch method. The prepared resinate complexes were microencapsulated by o/o solvent evaporation technique. These microcapsules […]

Abstract The purpose of this research was to formulate and optimize an effervescent Gastro retentive tablet formulation of Ondansetron hydrochloride using 32 factorial design. Gastroretentive tablets were prepared by direct compression method by incorporating HPMC K4M, HPC, Carbopol 934P, sodium bicarbonate and citric acid. A 32 Factorial design was applied systemically; the amount of HPMC […]

Abstract Skin acts as a major target as well as a principle barrier for topical drug delivery. The greatest challenge for dermal delivery is stratum corneum, and in order to improve its permeability, new formulation approaches have been investigated. The main requirement for topical anti-fungal treatment is that the drugs should penetrate into skin layers […]

Abstract It has been reported that about 40% of the compounds being developed by the pharmaceutical industries are poorly water soluble. The limiting factor to the in vivo performance of poorly water soluble drugs after oral administration their inadequate ability to be wetted by and dissolved into the fluid in the gastrointestinal (GI) tract. Therefore, […]

Abstract A simple, rapid, and precise reversed-phase liquid chromatographic method is developed for determination of paracetamol, aceclofenac, and chlorzoxazone in their ternary mixtures of commercial pharmaceutical preparation. This method uses C18 (Phenomenex) (150mm×4.6mm), 5 μm analytical column. Mobile phase is Methanol: Disodiumhydrogen orthophosphate (ph-3, 0.05M) 65:35 v/v. The instrumental settings are at a flow rate […]