Abstract In this work, we designed 4-phenylimidazole-2-thione by a simple grinding method and the resulting compound reacted with alkylating agents. Seven alkyl derivatives were obtained with yields of 13-58%. Substituted compounds in positions 1 and 3 (5a-c) were obtained with yields higher than those substituted in positions 1 and 2 (4a-c) or substituted in positions 2 (4). All synthesized compounds were characterized by 1H and 13C NMR and HRMS. This work opens a perspective to study the reactivity of 4-phenylimidazole-2-thione.
Keywords imidazol-2-thione, alkylation, reactivity.