Abstract Acetylsalicylic Acid (ASA) is the first active pharmaceutical ingredient (API) obtained by synthetic drug chemistry ‘ Therapeutic Chemistry’. ASA is one of the most commonly used analgesic and antipyretic medication worldwide, having been in clinical use for over 100 years. We synthesized this active pharmaceutical ingredient in Therapeutic Chemistry laboratoryof pharmacy department of Sidi Bel-Abbes and the yield obtained is 79.75%.The physicochemical quality control of the synthesized ASA is carried out according to the requirements of the European Pharmacopoeia 8th edition. The synthesized ASA was formulated as capsules and its content is 100.92 %. This work is an application of “Drug chain” notion; it would be very interesting to introduce it as coordinated practical work of Therapeutic Chemistry and Galenic Pharmacy modules for the third-year pharmacy students and residents in post-graduate.
Keywords Acetylsalicylic Acid; Aspirin; Active Pharmaceutical Ingredient; Drug Chain; Non-Steroidal Anti-inflammatory; Physicochemical Quality.