Synthesis and Quality Control of Benzyl Alcohol Used in Pharmacy as Solvent for Injectable Preparations

Abstract Benzyl alcohol is an aromatic alcohol, it’s used as asolvent for injectable preparations and classified as notorius effect excipient. It is contraindicated in infants and children less than three years of age because it causes a fatal toxic reaction. We synthesized this solvent in Therapeutic Chemistry laboratoryof pharmacy department of Sidi Bel-Abbes according the protocol using the Cannizzaro reaction and the yield obtained is 29.29%. The quality control of the synthesized benzyl alcohol is carried out according to the requirements of the European Pharmacopoeia 8th edition. It would be very interesting to introduce this work as a practical work of Therapeutic Chemistry module for the third-year pharmacy students and residents of Therapeutic Chemistry in post-graduate.

Keywords Benzyl alcohol, Solvent, Cannizzaro reaction, notorius effect excipient.

Google Scholar Citation

[Full Text: PDF]

Updated: January 20, 2024 — 8:05 am