Abstract The aim of the present study was to investigate the proliposome as potential carriers for efficient oral delivery of GIibenclamide in order to improve its bioavailability. The Glibenclamide loaded proliposomes were prepared using hydrogenated soyphosphatidylcholine (HSPC), cholesterol and using sorbitol as the carrier in varying ratios and characterized for entrapment efficiency, vesicle size, The formation of liposomes and surface morphology of optimized proliposome formulation was studied by optical and Electron transmission microscopy, respectively. In vitro release and dissolution study carried out provide an insight on the stability and enhanced dissolution of Glibenclamide from proliposome formulations. Several factors, level of lipid, content of cholesterol were investigated and optimized.
Keywords Proliposome, in-vitro, HSPC, Surface morphology.