Abstract Flavonoids are widely distributed in the plant kingdom and are thus important constituents of the human diet. Cassia arereh Del. is a small deciduous woody tree in the family Caesalpiniaceae. Cassia arereh has many medicinal attributes and potentials. Phytochemical screening of alcoholic extract of cassia arereh heartwood indicated presence of steroids, tannins, carbohydrates, saponins, terpenes, and flavonoids. From the ethanolic extract of Cassia arereh heartwood a flavanone has been isolated via a combination of chromatographic techniques. The structure of this flavonoid has been partially characterized by some spectral tools. The ethyl acetate extract and compound I have been screened for antimicrobial activity via the agar diffusion bioassay. Compound I exhibited moderate activity against Staphylococcus aureus. Compound I and the ethyl acetate extract showed partial activity against Psuedomonas aeruginosa and Escherichia coli.
Keywords Antimicrobial Activity, Flavanone, Cassia arereh Del.