Abstract This study was planned to identify and quantify the oil from Sudanese Cissus quadrangularis and to evaluate the antimicrobial activity of the extracted oil. Cissus quadrangularis is a perennial climber widely used in Sudanese ethnomedicine. This plant grows in warm tropics and may propagate through stem cutting. Cissus quadrangularis possesses digestive, anthelmintic and tonic properties. The plant is rich in ascorbic acid, calcium and carotene. It also contains flavonoids, steroids and terpenoids. GC- MS analysis of Cissus quadrangularis oil revealed the presence of the following major components: E,E,Z-1,3,12-nonadecatriene-5,14-diol(22.11%); R)-(-)-14-methyl-8-hexadecyn-1-ol (15.44%); trilinolein (12.17%); 9,12-octadecadienoyl chloride, (Z,Z)- (11.02%) and 9,12-octadecadienoic acid (Z,Z)-, methyl ester (8.67%). The oil was evaluated for its antimicrobial activity against five standard human pathogens. It showed moderate activity against Staphylococcus aureus and Pseudomonas aeruginosa.
Keywords Cissus quadrangularis, Oil, Constituents, Antimicrobail activity.