Abstract In this study, the constituents and antimicrobial activity of Lagenaria siceraria oil. have been investigated. Lagenaria siceraria Standley is a common fruit vegetable in the family Cucurbitaceae. The fruit has many uses in ethnomedicine. Fruit is used as diuretic, immunosuppressant, cardio-protective and cardio-tonic.Lagenaria siceraria possesses antioxidant, hypolipidemic and hepatoprotective properties. GC- MS analysis of Lagenaria siceraria oil revealed the presence of three major constituents: linoleic acid ethyl ester (57.96%); 9,12-octadecenoic acid methyl ester (19.56%) and hexdecanoic acid (10.15% %). The oil was screened for antimicrobial activity against five standard human pathogens by using the paper disc diffusion method. The oil showed moderate activity against Pseudomonas aeruginosa.
Keywords Lagenaria siceraria, Oil, Constituents, Antimicrobial Activity.