Abstract Paracetamol (PCM) is widely used as analgesic and antipyretic drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity. This study gives the information about hepatoprotective activity of Celastrus paniculatus leaves extract against paracetamol and ethanol induced hepatotoxicity. PCM induced hepatotoxicity was evaluated by an increase (P<0.05) in serum aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) activity and bilirubin level. PCM hepatotoxicity was manifested by an increase (P<0.05) lipid peroxidation, depletion of reduced glutathione (GSH) and catalase activity in liver tissue. Administration of ethanolic as well as aqueous plants extract [300mg/kg body weight of rat] protects the PCM induced lipid peroxidation, restored altered serum marker enzymes and antioxidant level towards normal. The results indicate hepatoprotective activity of all studied plants extract against PCM induced toxicity. Ethanolic extract was found more significant than the aqueous extract
Keywords Ethanol, hepatoprotective, paracetamol, silymerine.