Category: Uncategorized

Isolation of Phytochemical Constituent, Characterization and Pharmacognostic Studies of Stem and Leaves of Alangium Salvifolium Wang

Abstract Phytochemical constituent from Ethanolic Extract of Alangium Salvifolium [EEAS] was isolated using column chromatography and characterized by various spectroscopic studies such as Infrared (IR) spectra, Nuclear Magnetic Resonance (NMR) spectra and Mass Spectral studies. Results of various spectroscopic studies were interpreted and the interpreted results suggested that the isolated compound may be Di-demethoxyalanginol. Further […]

Analysis of Phytochemical Constituents, Anthelmintic and Insecticidal Properties of Leaf Extracts of Andrographis paniculata

Abstract Andrographis paniculata is an annual herb distributed in tropical countries and it is widely used in traditional medicines. The present study was aimed to investigate the presence of phytochemical constituents, anthelmintic and insecticidal properties of leaf extracts of A. paniculata. The highest percentage of extractive of 24.6% was observed for ethyl acetate extract and […]

Natural Occurring Thiirane Containing Compounds: Origin, Chemistry, and their Pharmacological Activities

Abstract This mini review describes research on rare and unusual natural and/or semi-synthetic thiirane-containing compounds isolated from plant, fungi, bacteria, and invertebrates. About 40 biologically active epithio metabolites demonstrate confirmed pharmacological activity, including antitumor, antimicrobial, and antibacterial effects. The structures, origin, and biological activities of epithio metabolites are reviewed. Utilizing the computer program PASS, some […]

Synthesis of Silver Nanoparticles Mediated by Stem Extract of Anredera cordifolia and Study of their Antimicrobial Properties

Abstract In this study, we synthesize silver nanoparticles using Anredera cordifolia stem extract as a reducing agent. We evaluate the antimicrobial properties of these nanoparticles against gram negative bacterial strain (Escherichia coli) and gram positive bacterial strain (Staphylococcus aereus). It took less than 10 minutes after mixing stem extract with silver nitrate solution for silver […]

Formulation and Characterization of an Antibacterial Cream from Lantana camara Leaf Extract

Abstract Purpose: The aim of the study was to evaluate the antibacterial activity of the ethanolic extract of the plant Lantana camara leaves against Staphylococcus aureus and E. coli species. Also to formulate effective and stable herbal antibacterial cream evaluates its physical and antibacterial properties. Methods: Disk diffusion method was used to assess antibacterial activity […]

Computational Prediction of Pharmacokinetic, Bioactivity and Toxicity Parameters of Some Selected Anti arrhythmic Agents

Abstract Many pharmacological agents are available for the treatment of cardiac arrhythmias. Arrhythmia may be classified on the basis of rate (bradycardia and tachycardia), mechanism (automaticity, re-entry, triggered) or duration (isolated premature beats; couplets). The treatment approach to arrhythmia depends firstly on whether or not the affected person is stable or unstable. This research investigation […]

Anti-Hepatitis B Viral Potentials of Ethanolic Stem Bark Extract of Vitex doniana and Lophira alata in Wistar Rats

Abstract Anti-hepatitis B viral activity of ethanol stem bark extracts of Vitex doniana and Lophira alata in Wistar rats was investigated. Forty-two (42) humanized albino rats were used for the study. The animals were divided into six (6) groups of seven (7) animals each. Groups II-VI were inoculated with hepatitis-B virus at the concentration of […]

Preparation of Microparticles of Polycaprolactone Containing Piroxicam to use in Chronic Inflammatory Diseases

Abstract The microparticles containing piroxicam were produced by the oil-in-water emulsion-solvent evaporation technique, and characterized by microscopy, loading efficiency, size distribution and polydispersity index, in vitro drug release and release kinetics. A total of 20 formulations were prepared and characterized. Microparticles presented micrometric size of 1.026µm to 3.541µm, distribution homogeneous with PDI below 0.35 with […]

Lead Poisoning causes Histoarchitectural Disruptions in Blood Marrow, Brain Regions and Muscles Histological Observations of Lead Poisoning Effects on Vital Body Tissues of Murine Models: Part I

Abstract The damaging effects of lead poisoning effects to various organs of the body have been severally reported; as well as the health complications they produce. There are however relatively few reports on the nature of such effects on body tissues- histology, most publications have rather addressed the resulting complications. The proper understanding of the […]