Abstract The purpose of this research was to formulate and optimize an effervescent Gastro retentive tablet formulation of Ondansetron hydrochloride using 32 factorial design. Gastroretentive tablets were prepared by direct compression method by incorporating HPMC K4M, HPC, Carbopol 934P, sodium bicarbonate and citric acid. A 32 Factorial design was applied systemically; the amount of HPMC K4M (X1) and Carbopol 934P (X2) were selected as independent variables. The time required for 50% drug release (T50%), release rate (Ko) and floating lag time (FLT) were selected as dependent variables. It was found that HPMC K4M, Carbopol 934P and their interaction had significant influence on the T50%, release rate (Ko) and floating lag time of the delivery system. The decrease in the release rate was observed with an increase in the concentration of the polymer system. Polymer with lower concentration HPMC K4M was shown to be beneficial than the absence of polymer Carbopol 934P in improving the floating properties of gastroretentive tablet. The observed difference in the drug release and the floating capacity of gastroretentive drug delivery system could be attributed to the difference in the water uptake capacity of the selected polymer.
Keywords Ondansetron hydrochloride, HPMC K4M, HPC, Carbopol 934P.