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Enantioselective reduction of ethyl 2-oxo-4-phenylbutyrate to ethyl (R)-2-hydroxy-4-phenylbutyrate using stereospecific carbonyl reductase KmCR: optimization of cultivation and reaction conditions

Abstract Ethyl (R)-2-hydroxy-4-phenylbutyrate ((R)-HPBE) is used as an intermediate in the production of angiotensin converting enzyme (ACE) inhibitors for treating various medical conditions. The study used Stereospecific carbonyl reductase (KmCR) enzyme for the asymmetric synthesis of (R)-HPBE. The optimization process involved varying IPTG concentration, induction temperatures, and induction times to determine the optimal culture conditions […]

Formulation of SDS Aided and Ethosomal Fluconazole Topical Gel for Improved Antifungal Effect

Abstract Fungal infections are the leading cause of death in both advanced and developing countries. This is due to the use of immunosuppressive treatments, long term use of antibiotics, and longer survival of immuno compromised individuals. Fluconazole, commonly known as Diflucan, is an antifungal drug used for the treatment of both systemic and superficial fungal […]

Formulation, Development & Characterization of Self Nanoemulsifying Drug Delivery for Fenofibrate

Abstract The aim of the present investigation is to preparation, Development & Characterization of Self Nanoemulsifying Drug Delivery for Fenofibrate. Accurately weighed Fenofibrate was placed in a glass vial, and required quantity of oil, surfactant, and co-surfactant were added. The mixture was mixed by gentle stirring and vortex mixing at 40ºC on a magnetic stirrer […]

Formulation, Development & Characterization of Floating Microspheres of Novel Calcium Channel Blockers

Abstract The present study was aimed at the development of stomach specific drug delivery systems using various approaches like mucoadhesive. From the stock solution, a suitable concentration (10g/ml) was prepared with pH 1.2 Hydrochloric acid buffer solution and UV scan was taken between 200-400 nm. The absorption maxima of 278 nm was selected and utilized […]

Development of a RP-HPLC Method for Simultaneous Estimation of Empagliflozin and Linagliptin

Abstract This work outlines the creation of a novel Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) method for the quantitative detection of Empagliflozin and Linagliptin in bulk and tablet forms. The approach is quick, accurate, sensitive, and sensitive. The approach may be utilised for regular monitoring of Empagliflozin and Linagliptin in industry in the assay of […]

Physico-chemical characterization of marble from Assiyo (Dassa-Zoumè) in Benin

Abstract The valorization of the natural resources located in Benin Republic, in particular, marble obtained from Assiyo (Dassa-Zoumè) was the purpose of this study. It was characterized to elucidate its properties for industrial applications. The results of the analysis by X-ray diffraction, infrared spectroscopy, X-ray fluorescence and thermal analysis showed that Assiyo marble is dolomitic […]

Levels of Heavy Metals in Tissues of Periwinkle (Tympanotonus fuscatus) in River Nun Estuary Around, Niger Delta, Nigeria

Abstract Heavy metal concentration in Tympanotonus fuscatus that were collected from the mangrove swamps of the Nun River estuary in the Niger Delta were analyzed in September, 2019. The samples were evaluated using Atomic Absorption Spectrophotometer (AAS). The concentrations ranged from 0.27mgkg-1 to 0.59mgkg-1, 1.57mgkg-1 to 3.27mgkg-1, 0.12mgkg-1, 0.22mgkg-1 and 0.83mgkg-1 to 1.12mgkg-1 for Cadmium […]

Formulation and Evaluation of Silver Nanoparticles for Effective Treatment of Topical Fungal Disease

Abstract Silver nanoparticle gels are a novel form of plant-based biopesticide that can be used as an alternative to chemical-based pesticides for the treatment of fungal diseases on tomato plants. In this investigation, our attention will be focused on the preparation and evaluation of colloidal silver nanoparticles as antibacterial and antifungal agents. The colloidal silver […]

Overview of the Methods for Seaweed Polysaccharide Extraction and Derivatization

Abstract With the increasing development and utilization of marine biological resources, the development of marine algae resources has also been developed to a certain extent, with abundant seaweed resources, which is the most important part of marine biological resources. The molecular structures of different alginpolysaccharides is significantly different, and the alteration of polysaccharide structure may […]