Abstract Fungal infections are the leading cause of death in both advanced and developing countries. This is due to the use of immunosuppressive treatments, long term use of antibiotics, and longer survival of immuno compromised individuals. Fluconazole, commonly known as Diflucan, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. This drug is an azole antifungal, in the same drug family as ketoconazole and itraconazole. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration [43]. This research was designed to formulate & evaluate different formulation of a topical gel containing fluconazole by using a polymer with different concentration as Carbopol 934p & Di potassium Hydrogen Orthophosphate. Methanol was used as a penetration enhancer. The evaluation of formulated fluconazole topical gel was carried out for a physical appearance, pH-value, spreadability, homogeneity, drug content. The formulated gel showed good physical characteristics. formulation EF2 select as a optimized formulation because of its good Spreadability (11.15±0.32), Viscosity (3310±25) and pH (6.80±0.35). The maximum % assay was also found in formulation F2 (99.45±0.25).
Keywords Formulation, SDS, Fluconazole, Topical Gel, Antifungal Effect.