Toxicological Effects of Saponin Extract from the Root of Bitter Kola (Garcinia kola) on the Biochemical and Haematological Parameters of Albino Rat Tissues

Abstract Toxicological assessment of any herbal medicine is to identify adverse effects and to determine limits of exposure level at which such effects occur. Assessment of haematological and biochemical parameters could be used to determine the extent of deleterious effect of foreign compound including plant extract on biological systems. Garcinia kola is a medicinal plant […]

Antioxidants and Oxidative Stress in Diabetes

Abstract Oxidative stress occurs when there is a disturbance in the balance between production of reactive oxygen species and antioxidant defense system. Reactive oxygen species are radicals such as superoxide and hydroxyl while non radical reactive oxygen species are hydrogen peroxide, hypochlorite and singlet oxygen. Auto oxidation of glucose in diabetes, glycation of anti oxidative […]

Trace Element Levels in Carpenters Exposed to Sawdust in Port Harcourt Metropolis, Rivers State, Nigeria

Abstract This study was carried out to determine the concentrations of trace elements in carpenters exposed to sawdust within Port Harcourt Metropolis, Rivers state. A total of thirty carpenters exposed to sawdust were compared with twenty-six apparently healthy individuals who work in an offices setting far away from saw dust as control. Atomic absorption spectrophotometer […]

Status of Herbal Drugs in Cardiomyopathy

Abstract Cardiomyopathy refers to group of diseases related to abnormal structure and functioning of the myocardium that triggers heart failure and death. These may be primary myocardial disorders which may have genetic, non genetic or acquired causes or may originate as a secondary consequence to number of conditions like ischemia, inflammation, infections, increased heart load […]

Determination of Total Phenolic/Flavonoid Content and Analgesic Properties of Different Extracts of Cochlospermum planchonii, Hook. F (Cochlospermaceae)

Abstract Medicinal plants contain substances that are used for therapeutic purposes or as precursors for synthesis of useful drugs. Since time past, they have been used in virtually all cultures as a source of medicine. The present study is to determine the total phenolic/flavonoid contents and analgesic properties of different leaf extracts of Cochlospermum planchonii […]

Screening of Metabolites of Endophytic Fungi Isolated from Leaves of Azadirachta indica for Antimicrobial and Cytotoxic Activities

Abstract Two endophytic fungi (AIn-L4 and AIn-L5) were isolated from the leaves of Azadirachta indica. The fungi were subjected to solid state fermentation on rice medium and the fungal secondary metabolites were extracted using ethyl acetate. The fungal extracts were screened for possible antimicrobial and cytotoxic activities. Also, some of the bioactive compounds of the […]

Effect of Moringa oleifera Crude Leaf Extract on Chlorpyriphos-induced Hepato-Toxicity in Wistar Albino Rats

Abstract The effect of Moringa oleifera crude leaf extract on Chlorpyriphos-induced hepato-toxicity in Wistar albino rats was investigated. Sixteen (16) adult Wistar albino rats of weighing about 100g and 250g were divided into a group of four (4) of four (4) rats each. Group I served as the control and were given a standard feed […]