Food dyes as blood cell dyes: An experimental and molecular modelling study to brilliant blue FCF and brown HT

Abstract In this work, the food dyes brilliant blue FCF and brown HT are experimentally tested as blood cell dyes. Quantum chemical calculations by Semi-Empirical (PM6) method were also performed. Calculated HOMO and LUMO orbitals energies, dipole moments, polar surface areas and entropies, suggested a higher affinity by the cells towards [blue CFC]-2 in comparison with [brown HT]-2. For both species, protonation of the benzene central ring (by NH3+ of amino acids present at the plasmatic membranes) is supposed based on the specific location of LUMO orbitals.

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Updated: May 7, 2017 — 3:32 pm
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