Abstract Spectroscopic examinations of flutamide solubility and 1H NMR measurements (flutamide and cyclocreatine) show that in aqueous solutions, molecules of the antitumor drugs tested stronger interact with macromolecules of cationic PAMAM G5-NH2 dendrimer compared with hydroxyl PAMAM G5-OH dendrimer. Solubility measurements show that cationic PAMAM G5-NH2 dendrimer macromolecules combine more (1.40 ± 0.16) flutamide molecules compared with PAMAM-OH G5 (0.45 ± 0.15). The results of 1H NMR spectroscopic measurements imply that the combination of flutamide with both dendrimers proceeds with the macromolecule functional groups placed on their surface.
Keywords dendrimer, PAMAM G5-NH2, hydroxyl-terminated, PAMAM G5-OH, flutamide, cyclocreatine, 1H NMR spectroscopy, solubility measurements.