Abstract A simple spectrophotometric method was developed and validated for determination of Sulpiride in pharmaceutical products. The method was based using two different solvent: 0.1 mol/L sodium hydroxide and 0.1 mol/L hydrochloric acid. The absorbance maximum was at 291 nm. The correlation coefficient were r=0.9994 (in 0.1 mol/L sodium hydroxide as solvent) and r=1.0000 (in 0.1 mol/L hydrochloric acid as solvent). The method was validated and results obtained for the assay of three different brands of Sulpiride capsules, hard. The proposed method was successfully applied to the spectrophotometric determination of Sulpiride according to ICH guidelines (linearity, accuracy, precision).
Keywords Sulpiride, Method development, Spectrophotometry.