Abstract The main objective of this study was to investigate the ameliorative effect of Gallic acid (GA) in BPA-induced toxicities of the prostate gland of adult male Wistar rats.Forty adult male Wistar rats were randomly assigned into four groups of ten animals each as follows: Group 1 (Control rats): 0.2 ml of corn oil; Group 2 (GA-treated rats): 20 mg/kg/day GA (dissolved in distilled water); Group 3 (BPA-treated rats): 10 mg/kg/day BPA suspended in 0.2 ml corn oil; Group 4 (BPA+GA-treated rats); BPA (10 mg/kg/day) with a concomitant GA (20 mg/kg/day). All treatments were orally administered for 14 days.BPA significantly increased (P<0.05) prostatic index and epithelial height of prostatic acini while inducing vascular congestion, hyperplasia of prostatic epithelium and atrophic tubules of the prostate gland. Concomitant treatment with GA ameliorated these alterations. BPA caused morphological alterations of the prostate gland of rats while concomitant treatment with GA ameliorated the alterations. Hence, low dose of GA serves a protective function against BPA-induced toxicity of the prostate gland of rats.
Keywords Bisphenol A, Gallic acid, hyperplasia, prostatic index, vascular congestion.