Abstract This paper reports the anti-hepatotoxic effect of the ethanol extract of the root of Terminalia macroptera (Guill and Perr) on carbon tetrachloride induced liver injury Wister rats. The animals were separated into five groups (A, B, C, D & E) consisting of three animals per group. The rats in group A were induced subcutaneously with 100mg/kg body weight and monitored for liver injury after 48 hours while groups C, D & E were treated with 210, 450 and 640 mg/kg of the extract intraperitoneally after inducement with carbon tetrachloride in addition to normal feed. High dose of the ethanol root extract of Terminalia macroptera (Guill and Perr) significantly reduced (p< 0.05) hepatitis in Wister rats. Preliminary qualitative phytochemical screening of ethanol root extract from this experiment showed the presence of alkaloids, flavonoids, resins, saponins, steroids, glycosides.