Abstract Urate oxidase catalyzes the degradation of uric acid, a product of purine disintegration pathway, into allantoin, carbondioxide and hydrogen peroxide. Owing to its efficacious uricolytic activity, urate oxidase employed to treat hyperuricemia and gout. Urate oxidase enzyme has been isolated from a wide range of organisms, including plants, animals and microorganisms. This review catalogues major sources of urate oxidase enzyme, its mechanism of action, modification, dosage and administration, past and present applications along with future prospects.
Keywords Urate oxidase, Uric acid, Gout, Applications.