Abstract Platanus kerrii Gagnep. belong to the family of Platanaceae, endemic to Southeast Asia, distributed on the mountains along the borders of countries Vietnam – Laos. From the stem bark of this plant, two substances were isolated in n-hexane extract. The structures of these compounds have been identified as betulinal (1) and oleanolic acid (2) by modern spectroscopic analysis. The cytotoxicity of these compounds was evaluated against hepatocellular carcinoma (Hep-G2) and human breast carcinoma cells (MCF-7). Betulinal exhibited medium cytotoxicity with Hep-G2 and MCF-7 with IC50 50.07, 85.63 (μg/ml) respectively while oleanolic acid showed no potiential anticancer with all cancer cell lines.
Keywords Platanus kerrii, stem bark, betulinal, oleanolic acid.