Investigation of Pharmaceutical Nanocapsules of Iron/Alginate Characters via Coacervation Technique

Abstract Microencapsulation is a process in which solid, liquid or gas components are covered with a septum. The present study has focused on the effect of stirring to produce ferric saccharate capsules with alginate coating applying the coacervation method so that we can obtain the best capsules for fortification of hydrated and dehydrated food products. At first, three methods including stirrer, ultrasonic and sonic bath were compared in order to select the best way of stirring. The experiments results showed that turning was provided by the stirrer method resulted in capsulation with spherical morphology and uniform distribution of surface. In this case the other factors such as the stirrer rotations, alginate concentration and calcium salt concentration were investigated. After studying the various conditions, it is suggested that the best Capsules were formed in alginate 3% at 500 rpm with Concentration of calcium chloride salt 1M and the resulted capsules by this method had a high efficiency and were more stable in hydrated and dehydrated food ingredients network for a long time.

Keywords microcapsules, coacervation, ferric saccharate, alginate, stirrer, ultrasonic, sonic bath.

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Updated: January 20, 2024 — 8:43 am