Abstract In the present investigation an attempt was made to develop solid oral formulations of Telmisartan which can be prepared using less complicated and expensive processes and fulfill all prerequisites for pharmaceutical use, i.e. long-lasting stability of the formulation under different climatic conditions and sufficient solubility of the active substance for sufficient gastrointestinal absorption in the slightly acidic and neutral pH region. Preferably, the formulations should have immediate release characteristics and a dissolution showing no essential pH dependency within the physiological relevant pH interval of the gastrointestinal tract. Tablets were evaluated for various parameters like, weight variation, content uniformity, in-vitro dissolution studies were performed using United States Pharmacopeia (USP) apparatus type II. The effects of concentration of meglumine, povidone and different alkalizers on the release rate of Telmisartan were studied. Telmisartan has poor and pH dependent water solubility in order to enhance its dissolution different alkalizers were used. Thus significantly increased the drug dissolution rate in intestinal stimulated fluid (pH 7.5), slightly acidic (pH 1.2) and water.
Keywords Telmisartan, wet granulation, in vitro dissolution.