Abstract In the present research work pulsatile drug delivery system of Zileuton tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by 30% concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated tablet formulations were subjected to various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopoeias limits. In-vitro release of Zileuton of core tablet formulations F1 showed faster drug release after 15 min. Faster drug release can be correlated with the high disintegration and friability observed in this study. The enteric coated formulations C1, C3 showed maximum drug release after 4 hour. Time dependent pulsatile drug delivery system has been achieved from tablet of formulation C3, C6 and C9 with 95.5%, 94.76% and 97.48% respectively.