Abstract Olive leaves have antidepressant, antihypertensive, anti-diabetes, antioxidant, analgesic and anti-inflammatory properties. Current study was carried cut to compare the effects of olive leaves and alprazolam on stress reduction of mice with type 2 diabetes. Sixty mice in the weight range of 25 to 30 were divided into six groups: control, diabetes, alprazolam and 50, 100, and 200mg/kg of olive leaves’ extract. All groups except control were induced diabetes three days before the test by intraperitoneal injection of 50mg/kg streptozotocin (STZ). After diagnosing the diabetes, groups were evaluated by plus evaluated maze. Open and closed arms entries and open and closed arms times were measured as anxiety indices. Obtained data were analyzed using SPSS22 program. Olive leaves extract increased open arm time in 50 and 100mg/kg doses which indicates anxiety reduction. Also, movement activities of mice were significantly increased in these doses. According to results, olive extract in 50 and 100mg/kg doses can be a good replacement for alprazolam to reduce diabetic patients’anxiety.
Keyword: olive leaves, stress, alprazolam, type2 diabetes, plus evaluated maze, mice.