Abstract In this work, the food dyes brilliant blue FCF and brown HT are experimentally tested as blood cell dyes. Quantum chemical calculations by Semi-Empirical (PM6) method were also performed. Calculated HOMO and LUMO orbitals energies, dipole moments, polar surface areas and entropies, suggested a higher affinity by the cells towards [blue CFC]-2 in comparison […]

Abstract Spectroscopic examinations of flutamide solubility and 1H NMR measurements (flutamide and cyclocreatine) show that in aqueous solutions, molecules of the antitumor drugs tested stronger interact with macromolecules of cationic PAMAM G5-NH2 dendrimer compared with hydroxyl PAMAM G5-OH dendrimer. Solubility measurements show that cationic PAMAM G5-NH2 dendrimer macromolecules combine more (1.40 ± 0.16) flutamide molecules […]

Abstract This study investigated the quality of drinking water supplied to the general drinking water network of Tripoli city-Libya (tap water and ground water). A total of four different sites were selected for this study. The chemical and biological parameters were carefully determined and compared to the WHO and the Libyan standard. The chemical analysis […]

Abstract In this paper, the electrochemical behavior of [H5PMo10V2O40] modified electrode glassy carbon electrode ([H5PMo10V2O40]/GCE) and its interaction with calf thymus DNA (ctDNA) were investigated using voltammetry. Modified electrode showed two pair of peaks at A1 (0.00) and A2 (0.179) during the anodic peaks sweep, while the counterpart to the two cathodic peaks are C1 […]

Abstract The binding behaviour of an azo dye, Allura Red AC with calf thymus deoxyribonucleic acid (ct-DNA) was investigated using UV-vis absorption spectroscopy, fluorescence quenching method, DNA melting and viscosity measurement. The physicochemical characteristics of Allura Red AC were investigated in 5 mM aqueous phosphate buffer of pH 7.0 at 25 °C. Spectrophotometric studies of […]

Abstract In the present work, a quantum chemical study (Semi-empirical,PM6 method) is performed using nitrogen mustards (HN1, HN2 and HN3)  as subjects in order to demonstrate that there is a close relationship between pharmacological activity and parameters such as formation enthalpy and number of conformers, which could, consequently, be employed as reliable QSAR descriptors. To […]

Abstract The acclaimed traditional use of vegetables as antidiabetic remedies has now been considered as one of the two basic diabetes mellitus control factors: food and medication. Allium species such as Allium cepa (onion, Hausa:Albasa) has attracted particular attention of modern medicine because of its widespread health use. In the present study the antidiabetic (hyperglycemic) potential […]

Abstract The use of herbal remedies, including corn silk, classified as Stigma Maydis or Zea mays, are popular as an alternative to standard Western allopathic medicine for a variety of problems, including prostate disorders, a diuretic as well as for bedwetting and obesity. In the present study the antidiabetic potential of methanol extract of cooked, […]

Abstract The genus Senecio from Patagonia, Argentina, contains several species, including Senecio coluhuapiensis. In the present study, we isolated 1-heneicosanol from this angiosperm. The structure of 1-heneicosanol was established on the basis of spectroscopic analysis and bibliographical data, and its microbiological activity evaluated. 1-heneicosanol presented activity against Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC […]

Abstract The purpose of the study was to develop a capsulated delivery system of surface solid dispersion (SSD) of loperamide (LOP) for intestinal delivery that has potential for enhanced drug release. For the preparation of SSDs, crospovidone, croscarmellose sodium and avicel PH 101 were screened for swelling capacity and in vitro drug adsorption. SSDs were […]