Abstract Caffeine is a psycho-stimulant and mild diuretic consumed around the world as natural components of chocolate, coffee and tea and as added components to soda and energy drinks. It’s used clinically and recreationally, motivated this study on its effects on the histomorphology of the hippocampus in a murine model. 24 albino mice was grouped […]

Abstract A sensitive and specific LC-UV method for the analysis of 5-Fluorouracil in human plasma has been developed and validated. 5-Fluorouracil was extracted from plasma by liquid-liquid method and separated on C18 reverse phase column using an elution gradient with a total run time of 11 min and detected by UV at 275 nm. For […]

Abstract Validation is an integral part of quality assurance; it involves the systematic study of systems, facilities and processes aimed at determining whether they perform their intended functions adequately and consistently as specified. A validated process is one which has been demonstrated to provide a high degree of assurance that uniform batches will be produced […]

Abstract Zea maize L (corn) is prevalent and agronomic crop being ubiquitously cultivated in many areas of  Tehsil Samahni of Azad Jammu and Kashmir (Pakistan), This is serving as staple food for mountainous communities of the area. The corn crop is being damaged due to many biotic and abiotic parameters. Fungal attack culminating into different […]

Abstract Acute loss of massive amounts of blood has been associated with disturbances of cardiovascular homeostasis. In this study, we evaluated the Lead-II electrocardiogram of Nigerian local dogs following acute loss of massive amounts of blood. Six local dogs aged between 6 and 8 months were used in this study. An estimated 30% of total […]

Abstract The aim of the present study is to detect the presence of palm oil and rice bran oil in virgin groundnut oil by Artificial Neural Networks (ANN) model. The oil samples were analyzed by FT-IR spectroscopy. They were classified as virgin groundnut oil, and two types of adulterated edible oil samples, such as palm […]

Abstract Information on plants used traditionally in Sudanese system of medicine is very scarce. Hence this study was undertaken to investigate the chemical constituents of Petroselinum crispum fixed oil and to evaluate its potential antimicrobial activity. 62 components were detected by GC-MS. Major components are: apiol (36.44%), 9-octadecenoic acid methyl ester (27.17%), 4-Methoxy-6-(2-propenyl)-1,3-benzodioxole12.12%) and 9, […]

Abstract The purpose of the present research was to formulate ocular inserts of norfloxacin along with bioadhesive polymers to sustain drug release and assess its antimicrobial potential against E. coli, in vitro. Ocular inserts of norfloxacin were prepared by film casting method using bioadhesive polymers HPMC/ SCMC/ sodium alginate/ chitosan/carbopol 934 and PVP K30 as […]

Abstract In the present research work pulsatile drug delivery system of Zileuton tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by 30% concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated tablet formulations were […]

Abstract Kenari (Canarium indicum L) belongs to Burseraceae family and grows abundantly in Indonesia especially in Eastern Indonesia. The kernel is often called kenari nut. The nut contains high amount  of lipid and various chemical substances, such as protein, phenolic compound, and tocopherol. The chemical composition is affected by some factors, especially area of origin. […]