Novel Pentacyanoferrate Complexes with Dinitrile Ligands (Malononitrile and Succinonitrile)

Abstract In the presente work the complexes Na3[Fe(CN)5(NC(CH2)nCN)] (n = 1 = malononitrile and n=  2 = succinonitrile) have been isolated and characterized by cyclic voltammetry, Uv-vis and FTIR spectroscopies. A metal to ligand charge-transfer transition was observed only for Na3[Fe(CN)5(NCCH2CN)] complexe (316 nm, 3,57×103 L mol-1cm-1). The succinonitrile complex of pentacyanoferrate(II) exhibits a band […]

Permeability Enhancement Study of Azithromycin: Effect of Co-Solvents and Surfactants

Abstract Azithromycin an antibiotic drug has a half-life of 50-60 hours and a bioavailability of 37-42 %, it undergoes appreciable first pass metabolism, has very poor aqueous solubility with an expected poor skin permeability. The aim of present work was to evaluate the effect of permeability enhancers: Tween 80, Tween 20, Sodium lauryl sulphate, propylene […]

Protective Effect of Gallic Acid against Bisphenol A-Induced Morphological Alterations of the Prostate Gland of Wistar Rats

Abstract The main objective of this study was to investigate the ameliorative effect of Gallic acid (GA) in BPA-induced toxicities of the prostate gland of adult male Wistar rats.Forty adult male Wistar rats were randomly assigned into four groups of ten animals each as follows: Group 1 (Control rats): 0.2 ml of corn oil; Group […]

Can bilirubin act as an indicator to predict coronary artery disease?

Abstract Introduction and Objective: Oxidative reactions are involved in the development of atherosclerosis. The formation of oxygen and peroxy radicals and LDL-cholesterol oxidation are some examples. The aim of this study was to evaluate the relationship between serum levels of bilirubin and coronary artery disease (CAD). Materials and Methods: We evaluated 85 patients and 92 […]

Antimicrobial Potency of Isolated Compounds from Syzygium cumini (L.) (Myrtaceae) root

Abstract Objective: To observe antibacterial, antifungal, MIC of two compounds from methanol root extract. Methodology: The powdered root extracted n-Hexane, acetone, chloroform and methanol using separating funnel. The antibacterial activity of S. cumini were tested against thirteen bacteria following by disc diffusion assay method and Ciprofloxacin was used as a control. Antifungal activity were tested […]

Phytochemical Investigation of Sapium baccatum: Identification of 3α-hydroxy-1α, 2α-epoxy lupan

Abstract Phytochemical investigation was carried with the crude toluene extract of the stem bark of Sapium baccatum. The isolated compounds were purified by column chromatography followed by crystallization. The structure of all compounds was established by chemical characterization and by the analysis of spectroscopic (IR, NMR and Mass) data and in some cases by comparison […]

The Nitrone Spin Trap 5,5-Dimethyl-1-pyrroline N-oxide prevents M1-like Phenotypic Switch of Lipopolysaccharide-Primed Macrophages

Abstract M1-like inflammatory phenotype of macrophages plays a critical role in tissue damage in chronic inflammatory diseases. M1-like macrophages produce reactive oxygen species, inflammatory cytokines (IL-1b, IFN-b), express inflammatory protein such as nitric oxide synthase (iNOS) and surface markers such as CD80; CD86; CD14; CD44. Because M1-like activation contributes to inflammation, decoding its mechanism may […]

Elemental impurities control by limit test and ICP-OES in Ciprofloxacin hydrochloride and Fluconazole of generic products marketed in Algeria

Abstract In this paper, we report the results of quality control based in elemental impurities determination of 12 raw materials samples of Ciprofloxacin hydrochloride and Fluconazole intended for the manufacture of their generic products marketed in Algeria. These samples were supplied by different pharmaceuticals companies. Heavy metals limit test and Inductively Coupled Plasma-Optical Emission Spectrometry […]

Theoretical and Experimental Contributions about the Usual Application of the Pseudo-First-Order Model in Kinetic Analysis of Oxyhemoglobin Deoxygenation

Abstract The reaction of hemoglobin with oxygen allows oxygenation of the body, ensuring homeostasis and cell survival. Although it occurs in four reversible, successive, and cooperative steps, the reaction is usually treated as a one-step reaction. This article aims to point out experimental and theoretical aspects relevant to the kinetic study of this reaction, but […]