Abstract Introduction: The impact of malaria scourge has been characterized by daunting challenges including antimalarial drug resistance. This necessitates the search for newer antimalarial drugs using approaches including drug repurposing. This study assessed whether Tinidazole (T) can be repurposed as an antimalaria in combination with artemether/lumefantrine (A/L) in Plasmodium berghei infected mice. Materials and Methods: […]

Abstract D. edulis is widely applied in Nigeria for treatment body pains, cough, diarrhea and fever. The study aims at isolating and characterizing compounds from the ethyl acetate and methanol extract of the plant stem bark. Healthy stem bark of the plant was collected, washed with distilled water, air dried, soxhlet extracted sequentially using ethyl […]

Abstract One of the large peripheral parts of the immune system is intestinal-associated lymphoid tissue. The immune structures associated with the mucous membrane are immunologically active tissue. About 80% of all immune cells in the body are associated with the intestinal mucosa. It is in close contact with the flow of microbial material, and serves […]

Abstract The paper presents data on the coronavirus disease COVID-2019 caused by the SARS-CoV-2 coronavirus, which was temporarily named 2019-nCoV (2019 novel coronavirus) until 11 February 2020. An outbreak of pneumonia of unknown etiology in Wuhan (Hubei province of China) which was first described in an official publication of the Chinese Office of the World […]

Abstract Background: Ginger (Zingiber officinale, family Zingiberaceae) is a perinneal plant whose its roots are used as a spice and for medicinal purposes. Aim: To investigate some pharmacological effects of ginger roots extract (GE) and its 6-Shogaol (6-SHO) compound in obese diabetic rat model. Materials and Methods: Sixty mature rats were allocated into 6 groups […]

Abstract In the treatment of rheumatoid arthritis (RA), it is recommended to use methotrexate or leflunomide as the first synthetic basic anti-inflammatory drug. The study included 27 patients from February to November 2019.According to the instructions for use, LEFNO was prescribed in the first 3 days at 100 mg / day, then at 20 mg […]

Abstract Proteinuria, which is a predictor of early diagnosis of chronic kidney disease, is also a risk factor for the development and progression of renal disease. The interdependence has a multi-faceted nature, and are built according to the type of feedback. On the one hand, the kidney can act as a target organ for most […]

Abstract According to the World Health Organization, 80% of the African population use herbal remedies for their primary health care and have encouraged the production of improved traditional medicines. Since traditional medicine consists often ofa combination of plants or parts of plants, our work focused on the evaluation of the antibacterial, antioxidant and cytotoxic activity […]

Abstract Lepidium sativum oil was characterized by GC-MS. A total of 25 constituents were identified. Major constituents are:cis-13-eicosenoic acid methyl ester (16.48%), 9,12-octadecadienoic acid (Z,Z)-, methyl ester (15.90 %), hexadecanoic acid methyl ester (13.11%) and 9,12,15-octadecatrienoic acid methyl ester(Z,Z,Z)-(10.16%). The antioxidant activity of Lepidium sativeum oilwas conducted by three methods: metal chelating, free radical (DPPH∙) […]

Abstract Clays and clay pots samples from two Southern Nigeria communities, Ara-Ekiti and Kono-Boue were studied to ascertain their mineralogical content and physicochemical parameters. The cation exchange capacity (CEC)were12.06, 5.97, 4.88 and 5.44 Cmol/Kg; bulk density, were 0.94, 1.20, 0.2 and 1.00 g/cm3, organic matter were 8.88, 3.29, 0.74 and 1.48% for Ara-Ekiti clay (AER), […]