Abstract Background: There is an abundance of herbal medicines that may introduce to cure the human patient for different syndromes with mild side effect. This study aimed to investigate In-vitro and In-vivo bioactivities potential of some Egyptian wild plants as anti-ulcerogenic on male albino rats. Polyphenols constitute a distinct group of natural compounds of medicinal plants as Monsonia nivea; Savignya parviflora; Heterocaryum subsessile, and Trigonella anguina ethanolic extracts exhibit a wide range of multi-physiological activities such as antioxidant, anti-inflammatory, and anti-ulcerogenic activities. 1st experiment In-vitro antioxidant properties DPPH radical assay; OH•; FRAP; TP; TF, NO, and flavonoid concentrations. Also, determine the Fe++/Ascorbate on mitochondria and microsomal fractions. Acid phosphatase; β-galactosidase; β-N-acetylglucosaminidase, and β- glucuronidase were determined in liver lysosomes against CCl4. the 2nd experiment carried out the In-vivo study, focusing the antioxidant, anti-inflammatory and anti-ulcerogenic activities of herbal cocktail ratio due to the best constituent results from the In-vitro study. Methods: Thirty-six male albino rats divided into six groups; 1st group: control. 2nd herbal cocktail group (100 mg/kg b.wt/day o.p) from Mn, Sp, Hs, and Ta extract with ratio 1:2:1:3 respectively, along with the experiment. The 3rd group treated with acetylsalicylic acid (500mg/kg b.wt/day o.p) for three successive days (positive group). The 4th group treated with herbal along 2 weeks then induction with ASA (protective group). The 5th group treated with ranitidine (27 mg/kg b.wt/day o.p) after induction with ASA (curative ranitidine group). The 6th group treated with herbal extract (27 mg/kg b.wt/day o.p) after induction with ASA (curative herbal cocktail group), the experiment lasted for 30 days. Results: Revealed data showed that the ASA induces a significant increase in blood leucocytes, neutrophils and stomach MDA, GSSG, NO, TNF-α, IL-6, and myeloperoxidase. On the other hand, ASA induces a significant decrease in blood RBCs and stomach GSH. Protective and curative effect of HC extract showed ameliorated effect for parameters near to control group. Conclusion: Obtained data concluded that individual wield herbal extract have In-vitro antioxidant, anti-inflammatory and In-vivo antioxidant, anti-inflammatory and anti-ulcerogenic properties due to reached flavonoids of the mixture.