Abstract This work analyzed ten capsules of amocycillin 500 mg each from drug resolving stores (shop 1), Opaclsas Pharmacy (shop 2), Happy Home Pharmacy (shop 3), Cheff Pharmacy Ltd (shop 4) Chimezie Medicine Stores (shop 5). The anti-hypertensive drugs (Nifedipine, 20 mg) were obtained from drug resolving stores (shop 1), Happy Home Pharmacy (shop 2), Cheff Pharmacy (shop 3), Chimezie Medicine stores (shop 4) and D-Global Pharmacy (shop 5). All capsules and tablets were obtained from different locations in Asaba. The analysis carried out on them are disintegration time, percentage uniformity of weight and percentage active ingredients they contain. The disintegration time for amoxicillin obtained from shop 1, shop 2, shop 3, shop 4 and shop 5 are: 11 minutes, 7 minutes, 8 minutes, 9 minutes and 10 minutes respectively. The percentage uniformity of weight for the five amoxicillin are 100 % each. The percentage active ingredients were found to be 104.9 %, 108.1 %, 109.98 %, 103.2 % and 109.3 % respectively. The disintegration time, percentage uniformity of weight and percentage active ingredients conformed to British pharmacopeia specifications. The disintegration time for the five antihypertensive drugs were found to be: 120 minutes, 20 seconds, 18 seconds, 25 seconds and 20 seconds respectively. The percentage uniformity of weight for the five antihypertensive drugs are 100 % each. The percentage active ingredients for them are 102.5 %, 95.4 %, 107.6 %, 101.5 % and 92.8 % respectively. Again, the disintegration time, percentage uniformity of weight and percentage active ingredients, all conformed to B.P. specification.
Keywords Amoxycillin 500mg, Nifedipine 20mg, disintegration time, percentage uniformity of weight, percentage active ingredients and B.P. specification