Abstract Sodium diethyldithiocarbamate is found in trihydrate form (SDDCT) as fine yellowish-white solid crystals. SDDCT is a chelating agent that primarily used in the analytical determination of copper, nickel and many other metals. It has been identified as metabolite of disulfiram, whose primary role is in the treatment of chronic arsenic poisoning. The toxicity of SDDCT in rats was reported after i.p. administration of 1500mg/kg was as safe in experimental animal. SDDCT has tendency to inhibit the nephrotoxicity induced by cisplatin in mice and also its effect over the organ distribution and excretion of cadmium. SDDCT induces the GSH oxidation process by increasing the concentration of oxyhemoglobin and also reported as excellent effect on neurotransmitters. Application of SDDCT as the spin trap in conjugation with Fe2+ to detect NO in brain, kidney, liver, and other tissues. Superoxide dismutase plays biological role as defense mechanism and get decrease in brain, liver and blood on administration of 1.5 g of DDCT/kg i.p. The effect of Tetramethylthiuram disulfide (TMTDS), Dimethyldithiocarbamate (DMDTC) was studies in male rat at a dose of 1g/kg as hepatic microsomal drug. Industrial or agricultural exposure of these compounds may impair hepatic metabolism and therefore enhance pharmacological activity of drug exposed individually.
Keyword: Sodium diethyldithiocarbamate trihydrate, Disulfiram, SDDCT, Oxyhemoglobin, SOD, GSH.