Abstract The kinetics and mechanism of oxidation of naproxen (NAP) by permanganate in alkaline medium have been studied. The stiochiometry has been observed to be 1:2 ratio of Mn(VII) and NAP consumed. The reaction shows first order with respect to oxidant. The reaction product was identified by LCMS. Activation parameters were calculated. The negative value of SΔ# (kJ mol-1)indicates the oxidation occurs via inner sphere mechanism
Keywords Kinetic, Thermodynamic Studies, Oxidation, Naproxen.