Abstract Skin acts as a major target as well as a principle barrier for topical drug delivery. The greatest challenge for dermal delivery is stratum corneum, and in order to improve its permeability, new formulation approaches have been investigated. The main requirement for topical anti-fungal treatment is that the drugs should penetrate into skin layers to ensure effective drug concentrations following topical administration. Types of the formulations as well as the physicochemical characteristics of drug molecules are effective parameters in topical delivery of drugs. Antifungal drugs should reach effective therapeutic levels in the viable epidermis after dermal administration. The drug of choice for topical fungal disease is Fluconazole. Fluconazole has a broad spectrum of activity that includes both dermatophytes and yeasts. The drug is particularly effective in the treatment of mucosal and cutaneous forms of candidiasis. Vesicular system (Liposomes and ethosomes) entrapped in Gel is one of the most promising approaches for topical delivery of active substances and has potential for new opportunities for topical application of Fluconazole in the fungal infections.
Keywords Deep Fungal Skin Infection, Fluconazole, Ethosome Gel, Liposome Gel.