Abstract In experiments on white rats of the Vistar line, the effect of GABA- mimetics on the duration of sleep caused by the test drug etaminal sodium in acute toxic hepatitis was studied. It has been established that in animals with acute toxic hepatitis, the duration of sleep of sodium etaminal is prolonged in comparison with healthy individuals. Experimental therapy with GABA – mimetics: aminalon and phenobarbital – led to a significant elimination of the disturbed pharmacodynamics of the test drug sodium etaminal compared to untreated animals, which indicated a hepatoprotective effect of GABA mimetics
Keywords GABA- mimetics, acute toxic hepatitis, hepatoprotector, pharmacodynamics of sodium etaminal.