Abstract This study describes an application and comparative evaluation of a HPLC and potentiometric titration methods to quantify the content of Propranolol in raw material. HPLC analysis were carried out using a C18 column and mobile phase composed of 1.6 g sodium lauryl sulfate, 0.31 g tetrabutylammonium dihydrogen phosphate, 1 ml sulfuric acid, 450 ml of water and 550 ml acetonitrile, with a flow rate of 1.8 ml/min and UV detection at 292 nm. The titration method of Propranolol was carried out using sodium hydroxide 0.1M as titrant and ethanol as solvent. The end point was potentiometrically determined. The content obtained by potentiometry is 100.49%, by HPLC is 100.01%. These results meet the required standard.
Keywords potentiometric titration, HPLC, content, propranolol, raw material.