Abstract Obesity is defined as the accumulation of adipose tissue, overweight and obesity are defined on the basis of body mass index and this is accompanied by an increased prevalence of comorbidities as type 2 diabetes, cardiovascular and metabolic disease in the population. The standard relationship between weight status and metabolic health is not applicable for some subtypes of individuals, the subtypes are known as “metabolically obese, but normal-weight”, and others are the “metabolically healthy, but obese” phenotypes. Regarding the problem of obesity there are areas of progress, greater social and political awareness, development of new treatments, and an extended base of evidence for its prevention and intervention. In contrast, the prevalence of this has increased rapidly in the last two decades, largely to the lifestyle of large cities. For the study of overweight, obesity and its physiopathology consequences, in addition to clinical studies in humans, are used animal models for understand the evolution of disease and support the development of therapies, the animal models, the current animal models generate rats with phenotype metabolically obese with overweight. In this research we proposed to evaluate the effect of intragastric administration of a hypercaloric emulsion composed of fructose syrup and edible vegetable oil on development of obesity in rats, we obtained rats with phenotype metabolically healthy but obesity only in eight weeks with adiposity index of 11.5 vs 5.9 of control group and 8.3 on sham group with fructose drinking solution.
Keyword: Overweight, Obesity, Adipocity index, Metabolic disorders, Hypercaloric emulsion.