Abstract Salicin, a glycoside isolated from Salix Alba, has provided us with most potent weapon, Acetyl-salicylic acid for killing pain. Separation of salicin was achieved on Agilent HPLC with Aclipse XDB-C18, 5 μm and 150mm X 4.6mm, injection volume 5 μl at flow rate of 1ml/min by using a binary pump system. The ratio of […]

Abstract Objectives: The main goal of the provided experiments was to test the influence of the used in the Disc Diffusion Method (DDM) Mueller Hinton agar (MHA) and to establish its reflection on the interpretation of the antimicrobial test. Methods: This study is based on developed microbiological methodology and outworked protocol for qualification of the […]

Abstract Terminalia bellerica is an important traditional Indian medicinal plant used in various ailments and rituals. The use of different parts of this plant like leaves and fruits as a medicament for treatment of various conditions is well documented in literature. Terminalia bellerica Roxb. (Combretaceae) is one of the ingredients of ayurvedic purgative medicament of […]

Abstract Febuxostat, is a medication used in the treatment of chronic gout and hyperuricemia. Febuxostat is a non-purine xanthine oxidase. It is a BCS class II drug. It exhibits poor bioavailability about 49% which is attributed to its poor bioavailability and poor solubility. The present work was aimed to overcome its limitation of poor solubility. […]

Abstract Infectious diseases caused by bacteria, fungi, parasites and viruses are still a major threat to public health. Their impact is particularly large in developing countries due to the relative unavailability of medicines and the emergence of widespread drug resistance. This has lead to the search of new antimicrobial agents mainly among plant extracts. As […]

Abstract Around forty percent of new chemical entities (NCEs) are reported to be poorly soluble in water. This translates to poor bioavailability and, thereby, limits the development of these molecules as drug candidates. It is suggested that nanoformulations of poorly-water soluble NCEs/Drugs are viable routes to increase the bioavailability of these molecules. The role of […]

Abstract Starches isolated from Scleroderma citrinum (SC) and Pleurotus ostreatus (PO) were investigated using physical and chemical tests. Total starch content was higher in SC (89.41 %) than PO (75.00 %). Amylose content was also higher in SC (38.50 %) than PO (21.70 %), while amylopectin, moisture and ash contents were higher in PO than […]

Abstract The objectives of this study were analysis of the secondary metabolite products from extract of marine Streptomyces sp. strain ND7a which isolated from sponges at Ha Tien Sea, Kien Giang province, Vietnam. Six bioactive compounds were identified in the organic solvent hexan-aceton and aceton-methanol. The identification of bioactive chemical compounds is based on the […]

Abstract Tapioca constitutes one of the staple foods prepared in different forms for consumption by many African dwellers, including Nigeria. It is a processed food from Manihot esculenta (cassava), rich in carbohydrate and contains linamarin that produces the toxic compound, hydrogen cyanide (HCN). Samples were collected from six selected areas: Bua-Yeghe, Sogho, Ebubu, Igbodo, Baa-Goi […]

Abstract The objectives of this study were analysis of the secondary metabolite products from extract of marine Penicillium citrinum strain ND7a which isolated from sponges at Ha Tien Sea, Kien Giang province, Vietnam. Sixteen bioactive compounds were identified in the organic solvent hexan-aceton and aceton-methanol. The identification of bioactive chemical compounds is based on the […]