Chemical Composition and Antinociceptive Effect of Pistacia atlantica desf. Essential Oil from Morocco

Abstract The chemical composition of crushed fruits and aerial parts essential oil, hydrodistilled from Pistacia atlantica DESF., were studied by gas chromatography-mass spectrometry, a significant difference in their chemical compositions were observed. The analgesic activity was carried out with the essential oil for its peripheral and central antinociceptive potentials on acetic acid-induced writhing and tail immersion test in rodents, […]

Effect of Prosopis africana Seed Extract on Lipid Profile of Experimentally Induced Prostatic Hyperplasia Animal Model

Abstract Benign prostatic hyperplasia (BPH) is an age-related disease, as the prostate enlarges, the layer of tissue surrounding it stops it from expanding, causing the gland to press against the urethra. The symptoms of BPH vary, but the most common is problems with urination which makes life unbearable. We investigated seed extract of Nigerian indigenous […]

Effect of Prosopis africana Seed Extract on Histology and Biochemical Indices of Prostate Functions in Testosterone and Estradiol induced Enlarged Prostate in Adult Rats.

Abstract Benign prostatic hyperplasia (BPH) is characterized as a slow, progressive enlargement of the prostate gland, which eventually causes obstruction and subsequent problems with urination.. We investigated seed extract of Nigerian indigenous plant Prosopis africana (PA) effect on BPH. BPH was induced in male rats weighing 250-350g through exogenous administration of testosterone and estradiol. A […]

A New Flavone O-Glycoside from Sida rhombifolia

Abstract A new Flavone O-Glycoside has been isolated from chloroform –methanol fraction of the aerial part of the Sida rhombifolia. The structure of the new compound were established as 3′,5,7-trihydroxy-4′-methoxy flavone-3-O-β-D-glucosyl(1″‘→3″)-β-D-glucopyranoside on the basis of spectral data using UV, IR, 1H NMR, 13C NMR and Mass. Keywords Sida rhombifolia, flavones O-glycoside. Google Scholar Citation [Full […]

Fabrication Development and Characterization of Extended Release Film Coated Formulation of Antimuscarinic Agent for the Treatment of Irritable Bowel Syndrome (IBS).

Abstract The aim of this current study was to develop extended release matrix film coated tablets of mebeverine hydrochloride to augment the therapeutic efficacy, diminish the frequency of administration and get better the patient compliance. The matrix film coated tablets were fabricated by wet granulation method, using different polymers such as Hydroxyl propyl methyl cellulose […]

The effectiveness of coconut shell activated carbon on the adsorption of heavy metal using different activating agents.

Abstract The effect of chemical activation on the adsorption of metals ions (Al2+, Cu2+, Ni2+, Mg2+and Fe2+) using waste Nigerian based coconut shell was investigated.  Coconut shell was carbonized at 400 ˚C and activated at 400, 500, 600 and 650 ˚C using four activating agents. The produced activated carbon was characterized which revealed that increase […]

Acylated Flavone O-Glycoside from Sida rhombifolia.

Abstract A new acylated flavone O-glycoside has been isolated from the methanol fraction of the root part of the Sida rhombifolia. The structure of the new compound has been established as, 4′,6-dihydroxy-7-methoxy flavone-3-O-α-(6″‘-acetyl glucosyl-β-1,4-rhamnopyranose) based on the spectral (UV, IR, 1H, 13C NMR and Mass) data. Keywords Acylated Flavone, O-Glycoside, Sida rhombifolia. Google Scholar Citation […]

Formulation, Development and Evaluation of Metformin Hydrochloride Extended Release Tablets.

Abstract The drug chosen for the present investigation, Metformin hydrochloride, is an orally active antidiabetic agent. It is effectively used in the treatment of non-insulin dependent diabetes mellitus (NIDDM) Type II. It is more appropriately referred to as antihyperglycemic agent and found to be well-tolerated and safe even on chronic use. The objective of this […]